NuclearReceptorCistrome

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Transcriptome
Species Cell type Cell origin Factor Condition Lab Reference Expression Index Differentially Expressed Genes
Human LnCaP prostate AR DHT(0hr),DHT(4hr),DHT(16hr),si_AR Myles Brown Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer. Cell 2009 July 24;138(2):245-256. Download Download
Human LnCaP prostate AR DHT(0hr,16hr) Peter Dervan Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide. Proc Natl Acad Sci U S A 2007 Jun 19;104(25):10418-23. Download Download
Human LnCaP prostate AR R1881(0hr,18hr) Charles Sawyers Histone deacetylases are required for androgen receptor function in hormone-sensitive and castrate-resistant prostate cancer. Cancer Res 2009 Feb 1;69(3):958-66. Download Download
Human LnCaP prostate AR R1881(3hr,6hr,12hr,24hr,48hr),R1881(0hr) as Cy3 control Arul Chinnaiyan An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression. Cancer Cell 2010 May 18;17(5):443-54. Download Download
Human VCaP prostate AR EtOH(48hr)+ERG,EtOH(48hr) as Cy3 control;R1881(48hr),EtOH(48hr) as control;R1881(48hr)+ERG,EtOH(48hr) as Cy3 control Arul Chinnaiyan An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression. Cancer Cell 2010 May 18;17(5):443-54. Download Download
Human LnCaP prostate AR R1881(0hr,48hr) Arul Chinnaiyan Proteomic interrogation of androgen action in prostate cancer cells reveals roles of aminoacyl tRNA synthetases. PLoS One 2009 Sep 18;4(9):e7075. Download Download
Human LnCaP prostate AR EtOH(18hr),R1881(18hr) Susan Logan Genome-wide impact of androgen receptor trapped clone-27 loss on androgen-regulated transcription in prostate cancer cells. Cancer Res 2009 Apr 1;69(7):3140-7. Download Download
Human LnCaP prostate AR DHT(1hr),no treatment as Cy3 control Yun Qiu Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination. Cancer Cell 2009 Apr 7;15(4):270-82. Download Download
Human LnCaP prostate AR DHT(6hr,24hr),RTI-6413-018(6hr,24hr),vehicle(6hr,24hr) David McDonnell Linking ligand-induced alterations in androgen receptor structure to differential gene expression: a first step in the rational design of selective androgen receptor modulators. Mol Endocrinol 2006 Jun;20(6):1201-17. Download Download
Human LnCaP prostate AR DHT(6hr,24hr),RTI-6413-018(6hr,24hr),vehicle(6hr,24hr) David McDonnell Linking ligand-induced alterations in androgen receptor structure to differential gene expression: a first step in the rational design of selective androgen receptor modulators. Mol Endocrinol 2006 Jun;20(6):1201-17. Download Download
Human abl prostate AR DHT(0hr),DHT(4hr),DHT(16hr),si_AR Myles Brown Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer. Cell 2009 July 24;138(2):245-256. Download Download
Human MCF-7 breast ESR1 E2(0hr,3hr,6hr,12hr) Myles Brown Genome-wide analysis of estrogen receptor binding sites. Nature Genetics 2006 Nov 11;38:1289-1297. Download Download
Human MCF-7 breast ESR1 E2(0hr,4hr,12hr,24hr) Kevin White Genomic antagonism between retinoic acid and estrogen signaling in breast cancer. Cell 2009 Jun 26;137(7):1259-1271. Download Download
Human MCF-7 breast ESR1 E2(12hr,24hr,48hr),control(12hr,24hr,48hr) Edison Liu Whole-genome cartography of estrogen receptor alpha binding sites. Plos Genet 2007 Jun;3(6):e87. Download Download
Human MCF-7 breast ESR1 E2(0hr,24hr) Marc Lippman GREB 1 is a critical regulator of hormone dependent breast cancer growth. Breast Cancer Res Treat 2005 Jul;92(2):141-9. Download Download
Human MCF-7 breast ESR1 E2(24hr,48hr),noE2(24hr,48hr) Marc Lippman Genes regulated by estrogen in breast tumor cells in vitro are similarly regulated in vivo in tumor xenografts and human breast tumors. Genome Biol 2006;7(4):R28. Download Download
Human MCF-7 breast ESR1 E2(0hr,1hr,2hr,4hr,8hr,12hr,24hr) Marc Lippman Genes regulated by estrogen in breast tumor cells in vitro are similarly regulated in vivo in tumor xenografts and human breast tumors. Genome Biol 2006;7(4):R28. Download Download
Human MCF-7 breast ESR1 E2(0hr,24hr) Benita Katzenellenbogen Impact of estrogen receptor beta on gene networks regulated by estrogen receptor alpha in breast cancer cells. Endocrinology 2006 Oct;147(10):4831-42. Download Download
Human MCF-7 breast ESR1 E2(0hr,24hr) Benita Katzenellenbogen Gene expression preferentially regulated by tamoxifen in breast cancer cells and correlations with clinical outcome. Cancer Res 2006 Jul 15;66(14):7334-40. Download Download
Human MCF-7 breast ESR1 E2(0hr,4hr) Henry Paik NA Download Download
Human MCF-7 breast ESR1 EtOH(24hr),E2(24hr) Simone Mader Mechanisms of primary and secondary estrogen target gene regulation in breast cancer cells. Nucleic Acids Res 2008 Jan;36(1):76-93. Download Download
Human MCF-7 breast ESR1 EtOH(3hr),E2(3hr) Lee Kraus Genomic analyses of transcription factor binding, histone acetylation, and gene expression reveal mechanistically distinct classes of estrogen-regulated promoters. Mol Cell Biol 2007 Jul;27(14):5090-104. Download Download
Human MCF-7 breast ESR1 E2(0hr,4hr,24hr) Barry Komm Estrogen Receptors alpha and beta as determinants of gene expression: influence of ligand, dose, and chromatin binding. Mol Endocrinol 2008 May;22(5):1032-43. Download Download
Human MCF-7 breast ESR1 siControl_vehicle,siControl_E2(12hr) Rod Russell Cooperative interaction between retinoic acid receptor-alpha and estrogen receptor in breast cancer. Genes Dev 2010 Jan 15;24(2):171-82. Download Download
Human U2OS cells osteosarcoma ESR1 noDoxy,Doxy,Doxy+E2(18hr) Dale Leitman Estrogen receptor [beta] binds to and regulates three distinct classes of target genes. J Biol Chem 2010 Jul 16;285(29):22059-66. Download Download
Human U2OS cells osteosarcoma ESR2 noDoxy,Doxy,Doxy+E2(18hr) Dale Leitman Estrogen receptor [beta] binds to and regulates three distinct classes of target genes. J Biol Chem 2010 Jul 16;285(29):22059-66. Download Download
Mouse 3T3-L1 adipocytes adipocytes PPARG premature,mature,siPPARG Mitchell A.Lazar Re-expression of GATA2 cooperates with peroxisome proliferator-activated receptor-gamma depletion to revert the adipocyte phenotype. J Biol Chem 2009 Apr 3;284(14):9458-64. Download Download
Mouse 3T3-L1 cells pre-adipocytes PPARG 3-isobutyl-1-methylxanthine, dexametha- sone, and insulin(0hr,6hr,12hr,2days,3days,4days,7days,28days) J Friedman Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity. Cell Metab 2007 Feb;5(2):115-28. Download Download
Mouse 3T3-L1 cells pre-adipocytes PPARG 3-isobutyl-1-methylxanthine, dexametha- sone, and insulin(0hr,6hr,12hr,2days,3days,4days,7days,28days) J Friedman Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity. Cell Metab 2007 Feb;5(2):115-28. Download Download
Human MCF-7 breast RARA AM580(0hr,24hr,48hr,72hr) Kevin White Genomic antagonism between retinoic acid and estrogen signaling in breast cancer. Cell 2009 Jun 26;137(7):1259-1271. Download Download
Human MCF-7 breast RARA siRARA_vehicle,siControl_vehicle Rod Russell Cooperative interaction between retinoic acid receptor-alpha and estrogen receptor in breast cancer. Genes Dev 2010 Jan 15;24(2):171-82. Download Download
Human NB4 cells hematopoietic stem cell RARA ATRA(0hr,4hr,12hr,24hr,48hr,72hr) Ji Zhang PML/RARalpha targets promoter regions containing PU.1 consensus and RARE half sites in acute promyelocytic leukemia. Cancer Cell 2010 Feb 17;17(2):186-97. Download Download
Human MCF-7 breast RARG CD437(0hr,24hr,48hr,72hr) Kevin White Genomic antagonism between retinoic acid and estrogen signaling in breast cancer. Cell 2009 Jun 26;137(7):1259-1271. Download Download
Human T47D breast PGR Progesterone(0hr,3hr,24hr) Myles Brown NA Download Download
Human HepG2 liver cells liver HNF4A siHNF4A,siControl Peter Burke NA Download Download
Mouse liver cells liver HNF4A siHNF4A,siControl David Waxman Liver-Specific Hepatocyte Nuclear Factor-4{alpha} Deficiency: Greater Impact on Gene Expression in Male than in Female Mouse Liver. Mol Endocrinol 2008 May;22(5):1274-1286. Download Download
Human A594 cells lung NR3C1 DEX(0hr,6hr) Peter Dervan Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expression. Proc Natl Acad Sci USA 2009 Sep 29;106(39):16598-16603. Download Download
Mouse RAW264.7 macrophages hematopoietic stem cell NR1H2 DMSO(24hr),GW3965+LG268(24hr) Antonio Castrillo Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR. Immunity 2009 Aug 21;31(2):245-58. Download Download
Human lymphoblastoid(GM10855) hematopoietic stem cell VDR calcitriol(0hr,36hr) Julian Knight A ChIP-seq defined genome-wide map of vitamin D receptor binding: Associations with disease and evolution. Genome Res 2010 Aug 24. [Epub ahead of print] Download Download
Human lymphoblastoid(GM10861) hematopoietic stem cell VDR calcitriol(0hr,36hr) Julian Knight A ChIP-seq defined genome-wide map of vitamin D receptor binding: Associations with disease and evolution. Genome Res 2010 Aug 24. [Epub ahead of print] Download Download